Case Report
Neonatal Leukaemia: A Case Report and Review of the Literature
Fedwa Cherrafi*,
Hiba Boumaazi,
Hicham Yahyaoui,
Mustapha Ait Ameur,
Mohammed Chakour
Issue:
Volume 9, Issue 2, April 2024
Pages:
14-17
Received:
1 June 2024
Accepted:
24 June 2024
Published:
15 July 2024
Abstract: Background: Acute leukemia has a particularly bad prognosis in the newborn era. Its prognosis is significantly poorer than in older youngsters. The occurrence of leukaemia in the neonatal period can present diagnostic challenges due to the rarity of the condition and its clinical presentation, which may be misleading or inconspicuous. Case report: A case of neonatal acute myeloblastic leukaemia (AML) in a newborn with trisomy 21 is presented herein. The patient was admitted with respiratory distress and a clinical examination revealed a facial dysmorphic syndrome, pallor, hepatosplenomegaly, and a bone marrow failure syndrome with bone marrow invasion by 36% myeloblasts, confirming the diagnosis of AML. The immunophenotyping results indicated that the patient had AML0, with a low CD13+ and CD33+ MPO myeloid population. During the patient's hospitalisation, a multi-resistant Klebsiella pneumoniae urinary tract infection was diagnosed, and septic shock was diagnosed after four days. Conclusion: Acute neonatal leukaemia is a rare and complex condition that requires the expertise of both neonatologists and paediatric haematologists.
Abstract: Background: Acute leukemia has a particularly bad prognosis in the newborn era. Its prognosis is significantly poorer than in older youngsters. The occurrence of leukaemia in the neonatal period can present diagnostic challenges due to the rarity of the condition and its clinical presentation, which may be misleading or inconspicuous. Case report: ...
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Research Article
Imaging the Impact: Computed Tomography Thorax in COVID-19 - A Comprehensive Review and Clinical Analysis
Yasmeena Maqbool*
Issue:
Volume 9, Issue 2, April 2024
Pages:
18-22
Received:
12 May 2024
Accepted:
4 June 2024
Published:
30 August 2024
DOI:
10.11648/j.ajlm.20240902.12
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Abstract: This comprehensive review and clinical analysis explore the pivotal role of thorax computed tomography (CT) in the context of COVID-19. As the world grapples with the ongoing pandemic, the need for effective diagnostic tools and management strategies remains paramount. This review meticulously examines the impact of thorax CT imaging on the understanding, diagnosis, and clinical management of COVID-19. The review encompasses an extensive analysis of the existing literature, shedding light on the nuances of thorax CT findings in COVID-19 patients. It explores the characteristic imaging features, such as ground-glass opacities, consolidations, and other pulmonary abnormalities, providing insights into the pathophysiology of the disease. Furthermore, the clinical analysis component synthesizes data from diverse studies to elucidate the diagnostic accuracy and sensitivity of thorax CT, particularly in cases where molecular testing may present challenges. The review also delves into the role of thorax CT in early detection, risk stratification, and longitudinal monitoring of patients with COVID-19, offering valuable perspectives for healthcare professionals. Importantly, considerations of radiation exposure and ethical use of thorax CT are addressed, emphasizing the judicious integration of imaging into clinical practice. The article concludes with practical recommendations for optimizing the utility of thorax CT in the broader context of COVID-19 diagnosis and patient care.
Abstract: This comprehensive review and clinical analysis explore the pivotal role of thorax computed tomography (CT) in the context of COVID-19. As the world grapples with the ongoing pandemic, the need for effective diagnostic tools and management strategies remains paramount. This review meticulously examines the impact of thorax CT imaging on the underst...
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