11-year Surveillance of the Epidemiological and Bacteriological Profile of Osteoarticular Infections in Children
Hajar Skali,
Fatima Zahrae Lazrak,
Asmae Lamrani Hanchi,
Tarik Salama,
El Mohtadi Aghoutane,
Redouane El Fezzazi,
Nabila Soraa
Issue:
Volume 7, Issue 2, March 2022
Pages:
23-27
Received:
17 February 2022
Accepted:
4 March 2022
Published:
12 March 2022
DOI:
10.11648/j.ajlm.20220702.11
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Abstract: Osteoarticular infections are an important cause of morbidity and mortality in the pediatric age group. Staphylococcus aureus is the most frequently identified. Early adequate and multidisciplinary care is required. Recently, an increasing incidence of OAI has been related to the improvement of identification methods of microorganism. The aim of this study was to describe, over a period of 11 years, the epidemiological and bacteriological profile of pediatric osteoarticular infections. This retrospective study conducted at the Microbiology Department of the University Hospital of Marrakech over a period of 11 years (2010-2020) including all strains isolated from synovial fluid or bone or joint samples obtained from the pediatric orthopedic surgery department. Six hundred thirty-nine samples were analyzed. The positivity rate to bacteria was at 56,5%. The mean age was 6,5 years. The male gender was predominant with a sex-ratio at 2,65. Arthritis represented 60%. The main etiological agent was Staphylococcus aureus, followed by Streptococcus Beta hemolytic group A (13,3%). Strains of Enterobacteriaceae (EB) were resistant to third-generation cephalosporins by production of Extended Spectrum Betalactamase in 45% of cases. An early diagnosis and start of antimicrobial treatment are crucial for good patient outcome, as well as the control of the infectious focus. Cytobacteriological examination is essential in order to isolate the germ, to study its susceptibility to antibiotics.
Abstract: Osteoarticular infections are an important cause of morbidity and mortality in the pediatric age group. Staphylococcus aureus is the most frequently identified. Early adequate and multidisciplinary care is required. Recently, an increasing incidence of OAI has been related to the improvement of identification methods of microorganism. The aim of th...
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Cutaneous Fusariosis by a Species of the Fusarium Dimerum in Acute Myeloblastic Leukemia Patient: A Case Report
Ikram Sebbane,
Fatimaezzahra Lahlimi,
Illias Tazi,
Asmaa Lahrougui,
Said Amal
Issue:
Volume 7, Issue 2, March 2022
Pages:
28-31
Received:
25 February 2022
Accepted:
21 March 2022
Published:
29 March 2022
DOI:
10.11648/j.ajlm.20220702.12
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Abstract: Fusarium is the second most common cause of fungi infections in the immunocompromised patients with the mortality rate over 80%. The Fusarium Dimerum is the less common species. In immunocompromised patients, spatially with prolonged neutropenia, the presenting features of Fusarium infections include persistent refractory fever, localised symptoms such as invasive infections, sinusitis, pneumonia, deep cutaneous infections, and disseminated infections. The dermatological manifestations include onychomycosis, a localised cellulitis at the site of injection, diffuse skin nodules or vesicles in disseminated disease. The diagnosis of skin fusariosis mainly based on cultures from the skin growing Fusarium species and skin biopsy. Amphotericin B represent the potential treatment for Fusarium infection, however, voriconazole is increasingly being used to treat infections unresponsive to the more conventional antifungals. Despite medical intervention, treatment of emerging fungal infections is a major challenge, with no standardized therapy and high mortality rates. We describe the case of Cutaneous fusariosis in a patient with acute myeloid leukemia (AML) undergoing induction chemotherapy. The patient had profound neutropenia and developed multiple ulcerous lesions. The diagnosis of cutaneous infection with Fusarium Dimerium was made on the basis of histopathological findings and skin biopsy culture. The patient was treated with liposomal amphotericin B but, neutropenia perduring, her clinical condition deteriorated with fatal outcome.
Abstract: Fusarium is the second most common cause of fungi infections in the immunocompromised patients with the mortality rate over 80%. The Fusarium Dimerum is the less common species. In immunocompromised patients, spatially with prolonged neutropenia, the presenting features of Fusarium infections include persistent refractory fever, localised symptoms ...
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Malignant Peripheral Nerve Sheath Tumour with Heterologous Differentiation: A Case Report
Rasheed Mumini Wemimo,
Afolayan Enoch Abiodun,
Jatto Hamza Ibrahim,
Adekunle Adebayo Ayoade,
Atiku Hafiz,
Odetayo Omolara Foluke
Issue:
Volume 7, Issue 2, March 2022
Pages:
32-36
Received:
4 March 2022
Accepted:
28 March 2022
Published:
20 April 2022
DOI:
10.11648/j.ajlm.20220702.13
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Abstract: Malignant peripheral nerve sheath tumour is one of the rare soft tissue tumours in the younger age group. The tumour arises from peripheral nerves with a predominant lesion on the extremities or limbs, head and neck, and trunk. It can arise de novo also known as sporadic or in patients with neurofibromatosis type 1. It is an infiltrative, aggressive tumour with a high rate of recurrence and metastases. The microscopic examination of both NF1 gene-associated and sporadic MPNST are similar but different prognoses aided and abetted by other co-morbid factors or disease conditions. Histologic examination of the surgically resected specimen is the goal standard for diagnosis with an ancillary test comprising immunostaining of the tumour cells. This tumour has the propensity to undergo diverse differentiation towards osseous, chondroblastic, and rhabdomyoblastic cells. The rhabdomyoblastic differentiation is strongly associated with a poor prognosis. Thus, creating a diagnostic challenge for general pathologists and pathologists in the trainee. The specific cause of this tumour is not known but is strongly linked to Neurofibromatosis type 1 in a few groups of patients with multiple cutaneous plexiform neurofibromas which are not concordant with the index case. We, therefore, present a sporadic subcutaneous MPNST with heterologous differentiation comprising rhabdmyoblastic cells, chondroblast, and osseous in a 15-year-old woman.
Abstract: Malignant peripheral nerve sheath tumour is one of the rare soft tissue tumours in the younger age group. The tumour arises from peripheral nerves with a predominant lesion on the extremities or limbs, head and neck, and trunk. It can arise de novo also known as sporadic or in patients with neurofibromatosis type 1. It is an infiltrative, aggressiv...
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