The Role of Myelogram in Diagnosis of Malignant Hemopathies
Skali Hajar,
Lazrak Fatima Zahrae,
Yahyaoui Hicham,
Ait Ameur Mustapha,
Chakour Mohamed
Issue:
Volume 6, Issue 5, September 2021
Pages:
70-76
Received:
18 September 2021
Accepted:
5 October 2021
Published:
12 October 2021
Abstract: The myelogram is an essential investigation for the diagnosis and management of malignant hemopathies. The final interpretation requires the integration of peripheral blood count and smear, with the results of supplementary tests such as immunophenotyping, cytogenetic analysis and molecular genetic studies as appropriate, in the context of clinical and other diagnostic findings. This retrospective study conducted at the Hematology Laboratory of the Military hospital Avicenna in Marrakech over a period of two years, from January 2018 to December 2019, aimed to evaluate the practice and the contribution of the myelogram in diagnosis in patients in the Hematology Laboratory and to report the epidemiological profile of malignant hemopathies diagnosed in our Laboratory. In our study, out of 420 myelograms received in the Hematology Laboratory of the military hospital in Marrakech, 70 cases (17%) of malignant hemopathies were collected. The predominant age range was 61 to 70 years old. The male gender was predominant (64%) with a sex-ratio at 1,8. The clinical indications of myelogram were dominated by anemic syndrome, tumoral syndrome. Biologically, the Peripheral Blood count and smear abnormalities were the most frequent. Acute leukemias were accounted for 35% of all malignant pathologies diagnosed in our laboratory of which 79% myeloid, 21% lymphoid. Multiple myelomas were found in 33%, myelodysplastic syndromes in 17% and Chronic myeloid leukemia in 9%. The role of the myelogram in diagnostic of malignant hemopathies is based on its good interpretation which is directly linked to the rigor of its realization.
Abstract: The myelogram is an essential investigation for the diagnosis and management of malignant hemopathies. The final interpretation requires the integration of peripheral blood count and smear, with the results of supplementary tests such as immunophenotyping, cytogenetic analysis and molecular genetic studies as appropriate, in the context of clinical...
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Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech
Lazrak Fatima Zahrae,
Skali Hajar,
Rahali Fatima Zahra,
Yahyaoui Hicham,
Sayagh Sanaa,
Ait Ameur Mustapha,
Chakour Mohamed
Issue:
Volume 6, Issue 5, September 2021
Pages:
77-82
Received:
23 September 2021
Accepted:
11 October 2021
Published:
21 October 2021
Abstract: Thrombocytopenia is defined by a number of circulating platelets less than 150 G/l. Realization of a blood smear is necessary to find out its reality and to study platelet morphology. Several mechanisms may be involved: peripheral thrombocytopenia by destruction, consumption or hypersplenism and central thrombocytopenia dominated by haematological malignancies. The aim of this study is to describe thrombocytopenia in children received at our hospital. This is a prospective study, including all thrombocytopenic children from 0 to 15 years old who received a blood count at the Hematology Laboratory for 1 month. A blood smear will be systematically performed for false thrombocytopenia and for the study of platelet morphology. The etiological determination will be made by the exploitation of the files at the level of clinical services. The average age of patients was 4 years with extremes ranging from 2 daysAt 15 years old, predominantly female, 53% (24 girls/21 boys), with a sex ratio of 0.87. Of the 45 cases, 42% were from a completed follow-up pregnancy, 15% had the concept of consanguinity in their antecedents. The myelogram showed AML in 7% of cases, ALL in 4%, 9% in leishmania, LMMC in 2% and myelofibrosis in 2%. Infection, leukemia and leishmaniasis with 39%, 25% and 11% are the most implicated causes in the development of thrombocytopenia in children in the study population. Thrombocytopenia is defined in children by a platelet count of less than 150 G/L, normal values before the age of 15 years are 95% of children between 165 and 473 G/L with a median value of 299 G/L [1]. The discovery of a fortuitous thrombocytopenia during a hemogram or when the child presents to the emergencies with cutaneo-mucous haemorrhagic manifestations must initiate a rigorous diagnosis.
Abstract: Thrombocytopenia is defined by a number of circulating platelets less than 150 G/l. Realization of a blood smear is necessary to find out its reality and to study platelet morphology. Several mechanisms may be involved: peripheral thrombocytopenia by destruction, consumption or hypersplenism and central thrombocytopenia dominated by haematological ...
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