Volume 5, Issue 6, November 2020, Page: 174-179
Association Between Neonatal Hyperbilirubinemia and Serum Zinc Levels in Dhaka City of Bangladesh
Mohammad Anwar Hossain, Institute of Biological Sciences, Rajshahi University, Rajshahi, Bangladesh
Mohammad Nazmul Huda, Department of Ayurvedic Medicine, Government Unani and Ayurvedic Medical College and Hospital, Dhaka, Bangladesh
Mohammad Ekramul Islam, Department of Pharmacy, Rajshahi University, Rajshahi, Bangladesh
Ashik Mosaddik, Department of Pharmacy, Rajshahi University, Rajshahi, Bangladesh
Saiful Islam, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Quddusur Rahman, Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Firoza Begum, Department of Fetomaternal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Sheikh Mizanur Rahman, Department of Microbiology, Institute of Public Health, Dhaka, Bangladesh
Tarun Kanti Paul, Department of Microbiology, Sylhet Muhammad Ataul Gani Osmani Medical College, Sylhet, Bangladesh
Received: Nov. 21, 2020;       Accepted: Dec. 9, 2020;       Published: Dec. 16, 2020
DOI: 10.11648/j.ajlm.20200506.14      View  71      Downloads  49
Abstract
Neonatal hyperbilirubinemia is a common clinical condition in the first week of neonatal life. The common causes are haemolytic disease of the newborn (rhesus), ABO incompatibility, glucose-6-phosphate dehydrogenase deficiency, spherocytosis and infection. Any study was not conducted in Bangladesh to find out the correlation between neonatal hyperbilirubinemia and zinc level. So, the objective of this was to evaluate the correlation between the level of serum zinc and neonatal hyperbilirubinemia in Dhaka city of Bangladesh. This cross sectional study was done at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Total 594 numbers of sample were collected from neonatology department of BSMMU from January 2016 to April 2019 and samples were divided in two groups. Case group and control group consists 319 and 275 numbers of sample respectively. All the laboratory parameters were done at clinical pathology department of BSMMU by automated analyzer machine and strictly followed quality control. Data obtained were analyzed using the Statistical Package for the Social Science (SPSS) version 20. Results were considered statistically significant if p<0.05. The result showed that the level of serum bilirubin was 171.14 mg/L and 35.42 mg/L and the level of serum zinc was (0.50 mg/L) and (0.68mg/L) in case and control group respectively. The bilirubin level was significantly (p<0.001) high in case group and zinc level was significantly (p<0.001) decreased in case group when compared with control group. Is also showed there was a significant (p value<0.001) correlation between hyperbilirubinemia and serum zinc level in this study. Therefore, it can be concluded, the deficiency of zinc may have a relationship followed by in neonatal hyperbilirubinemia.
Keywords
Neonatal, Hyperbilirubinemia, Serum Zinc, Severe Neonatal Jaundice (NNJ)
To cite this article
Mohammad Anwar Hossain, Mohammad Nazmul Huda, Mohammad Ekramul Islam, Ashik Mosaddik, Saiful Islam, Quddusur Rahman, Firoza Begum, Sheikh Mizanur Rahman, Tarun Kanti Paul, Association Between Neonatal Hyperbilirubinemia and Serum Zinc Levels in Dhaka City of Bangladesh, American Journal of Laboratory Medicine. Vol. 5, No. 6, 2020, pp. 174-179. doi: 10.11648/j.ajlm.20200506.14
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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