Volume 5, Issue 1, January 2020, Page: 32-41
Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment
Nafiu Amidu, Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana
Benedict Boateng Antuamwine, Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana
Martin Awe Akilla, Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana
William Kwame Boakye Ansah Owiredu, Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Otchere Addai-Mensah, Department of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Peter Paul Dapare, Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana
Eric Mishio Bawa, Department of Biomedical Laboratory Science, University for Development Studies, Tamale, Ghana
Received: Jan. 8, 2020;       Accepted: Jan. 31, 2020;       Published: Feb. 14, 2020
DOI: 10.11648/j.ajlm.20200501.15      View  288      Downloads  86
PIH accounts significantly for maternal and perinatal mortality, especially in rural communities. The sudden onset of PIH and the lack of definitive case management is worrisome. The study analysed differential leucocytes count on PIH outcomes. This is a case-control study of 40 PIH (8 GH, 16 PE and 16 EC) and 60 normotensive women who visited the Bolgatanga Regional Hospital, Ghana. Data on socio-demographics, clinical history and laboratory evaluations on blood and placental tissues were collected and analysed. Lymphocytes count was markedly increased in PIH women, while total leucocytes, neutrophils and NLR were significantly decreased. Lymphocytes count increased with severity of PIH (p=0.0037). A correlation (r=-0.9565, p<0.0001) between lymphocyte and neutrophil counts was observed among PIH subjects. Oxidative stress was more associated with PIH compared to controls. Stillbirths was associated with PIH mothers with high leucocytes count. NLR (AUC; 0.857, p<0.0001) and lymphocytes count (AUC; 0.822, p<0.0001) were optimal for prognosis of PIH. Wide variations in NLR and lymphocytes count during pregnancy necessitates urgent attention.
Preeclampsia, Gestational Hypertension, Differential Leucocytes Count, Neutrophil-to-Lymphocyte Ratio, Risk Assessment, Stillbirth
To cite this article
Nafiu Amidu, Benedict Boateng Antuamwine, Martin Awe Akilla, William Kwame Boakye Ansah Owiredu, Otchere Addai-Mensah, Peter Paul Dapare, Eric Mishio Bawa, Leucocyte Differential Count and Pregnancy Induced Hypertension: Implication for Risk and Disease Assessment, American Journal of Laboratory Medicine. Vol. 5, No. 1, 2020, pp. 32-41. doi: 10.11648/j.ajlm.20200501.15
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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