Volume 5, Issue 1, January 2020, Page: 28-31
Macrophagic Activation Syndrome (MAS) Revealing Systemic Lupus Erythematosus
Sana Aourarh, Department of Laboratory of Hematology of Faculty of Medicine, University Cadi Ayyad, University Hospital Mohammed VI, Marrakech, Morocco
Fatima Zahra Lazrak, Department of Laboratory of Hematology of Faculty of Medicine, University Cadi Ayyad, University Hospital Mohammed VI, Marrakech, Morocco
Saida Eddyb, Department of Laboratory of Hematology of Faculty of Medicine, University Cadi Ayyad, University Hospital Mohammed VI, Marrakech, Morocco
Adil Jahdaoui, Department of Laboratory of Hematology of Faculty of Medicine, University Cadi Ayyad, University Hospital Mohammed VI, Marrakech, Morocco
Sanae Sayagh, Department of Laboratory of Hematology of Faculty of Medicine, University Cadi Ayyad, University Hospital Mohammed VI, Marrakech, Morocco
Mustapha Ait Ameur, Department of Laboratory of Hematology of Faculty of Medicine, University Cadi Ayyad, Military Hospital Avicenna, Marrakech, Morocco
Mohamed Chakour, Department of Laboratory of Hematology of Faculty of Medicine, University Cadi Ayyad, Military Hospital Avicenna, Marrakech, Morocco
Received: Dec. 26, 2019;       Accepted: Jan. 15, 2020;       Published: Feb. 10, 2020
DOI: 10.11648/j.ajlm.20200501.14      View  555      Downloads  168
Abstract
Introduction: Macrophagic activation syndrome (SAM) or hemophagocytic lymphohistiocytosis is an anatomoclinical entity resulting from an inappropriate proliferation and activation of macrophagic cells. This rare but serious syndrome can be primary or secondary to certain pathologies dominated by infections and neoplasias. More rarely, it is secondary to connectivitis, in particular to systemic lupus erythematosus (LES). The aim of this work is to report the case of SAM revealing a systemic lupus erythematosus and to discuss the triggering factors. Observation: A 27-year-old patient who presents to the emergency room for arthralgia evolving for a week in a context of fever and deterioration of the general state hospitalized in the nephrology department for bicytopenia and functional renal failure. The hemogram showed anemia at 10.7 g/dL, normocytic, normochromic, aregenerative (reticulocytes at 18 G/L), hyperleukocytosis at 10.5 G/L and platelets at the lower limit of normal at 158 G/L (338 G/L in September 2006). In view of argenerative anemia, a myelogram was performed showing the presence of hemophagocytosis figures. The remainder of the biological examination revealed hyperferritinaemia at 1017 ng/mL with an increase in LDH 930 U/Let a CRP at 18.15 mg/L. The patient was transferred to the internal medicine department for etiological assessment, clinical and paraclinical examinations showed arthritis with deep ADP and pleural mass, leuconeutropenia with native DNA and positive antinuclear antibodies (ANA) as well as the coombs test which was positive, The diagnosis of SLE was retained in her on the criteria of the ACR.
Keywords
Hemophagocytic Lymphohistiocytosis, Systemic Lupus Erythematosus, Autoimmunity
To cite this article
Sana Aourarh, Fatima Zahra Lazrak, Saida Eddyb, Adil Jahdaoui, Sanae Sayagh, Mustapha Ait Ameur, Mohamed Chakour, Macrophagic Activation Syndrome (MAS) Revealing Systemic Lupus Erythematosus, American Journal of Laboratory Medicine. Vol. 5, No. 1, 2020, pp. 28-31. doi: 10.11648/j.ajlm.20200501.14
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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