Volume 4, Issue 4, July 2019, Page: 70-73
Type 2 Diabetes and Vitamin D Status
Rachidi Meriem, Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
Tali Abdelali, Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
Zahire Hanane, Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
El Ansari Nawal, Departement of Endocrinology, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
Chabaa Laila, Laboratory of Biochemistry, Arrazi Hospital, Mohammed VI Hospital Center of Marrakech, Marrakech, Morocco
Received: Jan. 31, 2019;       Accepted: Jul. 3, 2019;       Published: Jul. 19, 2019
DOI: 10.11648/j.ajlm.20190404.11      View  34      Downloads  7
Vitamin D (Vitamine D), classically recognized as an important player in bone and phosphocalcic metabolism, has shown, through recent studies, its involvement in the pathogenesis of insulin resistance in case of deficiency. The aim of this work is to describe the profile of vitamin D in a type 2 diabetic population and to correlate the vitamin D status with the different metabolic parameters in this population admitted in the University Hospital of Marrakech. It is a descriptive cross-sectional study of a population of type 2 diabetic patients, coming for a follow-up assessment of diabetes and having performed an evaluation of the level of 25 hydroxy vitamin D3 in blood. Demographic, clinical, evolutionary and biological data were collected. The mean of 25 (OH) vitamin D3 was 12.55 ± 8.14 ng / ml for the group, and was 13.15 ± 8.93 ng / ml for women and 11.82 ± 7.31 ng / ml for men. These patients were classified into three groups: Group 1: 25 (OH) D < 10 ng / ml objectified in 37 patients (44%); group 2: 25 (OH) D between 10 and < 29 ng / ml in 43 patients (51.2%) and group 3: 25 (OH) D > 30 ng / ml present in 4 patients in this population (4, 8%). Several studies have reported an association between vitamin D status and the development of type 2 diabetes. Experimental studies have suggested that vitamin D deficiency decreases insulin sensitivity, carbohydrate tolerance and β-pancreatic function. The data of this work underline the high frequency of vitamin D deficiency in the Moroccan population suffering from type 2 diabetes.
Vitamin D, Type 2 Diabetes, Insulin Resistance
To cite this article
Rachidi Meriem, Tali Abdelali, Zahire Hanane, El Ansari Nawal, Chabaa Laila, Type 2 Diabetes and Vitamin D Status, American Journal of Laboratory Medicine. Vol. 4, No. 4, 2019, pp. 70-73. doi: 10.11648/j.ajlm.20190404.11
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
T. Mezza, G. Muscogiuri, G. P. Sorice, A. Prioletta, E. Salomone, A. Pontecorvi, A. Giaccari. Vitamin D Deficiency: A New Risk Factor for Type 2 Diabetes?Ann Nutr Metab 2012; 61: 337–348.
S. Safi, H. Ouleghzal, I. Khaldouni, H. Hassikou, L. Ballouch, Y. Bamou, L. Hadri. Statut de la vitamine D chez les patients diabétiques de type 2 marocains. Médecine des maladies Métaboliques - Février 2015 - Vol. 9 - N°1.
Mitri J, Pittas AG. 25 (OH) D: 25-hydroxy-vitamin D. Endocrinol Metab Clin North Am 2014; 43: 205-32.
Pilz S, Kienreich K, Rutters F, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diabetes Rep 2013; 13: 261-70.
P. E. Norman and J. T. Powell. Vitamin D and Cardiovascular Disease. Circ Res. 2014; 114: 379-393.
Christy S Maxwell and Richard J Wood. Update on vitamin D and type 2 diabetes. Nutrition Reviews 2011; Vol. 69 (5): 291–295.
Cavalier E, Delanaye P, Souberbielle JC, Radermecker RP. Vitamin D and type 2 diabetes mellitus: where do we stand? Diabetes Metab. 2011; 37: 265-72.
Nobécourt E, Diedisheim M, Radu A, et al. Carence en vitamine D chez les diabétiques. Conséquences sur le métabolisme phosphocalcique. Diabetes Metab 2010; 36 (Special issue 1): A62 [Abstract P95].
Lee JI, Oh SJ, Ha WC, et al. Serum25-hydroxyvitamin D concentration and arterial stiffness among type 2 diabetes. Diabetes Res Clin Pract 2012; 95: 42-7.
Yu JR, Lee SA, Lee JG, et al. Serum vitamin D status and its relationship to metabolic parameters in patients with type 2 diabetes mellitus. Chonnam Med J 2012; 48: 108-15.
Kos E, Liszek MJ, Emanuele MA, et al. The effect of metformin therapy on vitamin D and vitamin B12 levels in patients with type 2 diabetes mellitus. EndocrPract 2012; 18: 179-84.
Payne JF, Ray R, Watson DG, et al. Vitamin D insufficiency in diabetic retinopathy. EndocrPract 2012; 18: 185-93.
Suzuki A, Kotake M, Ono Y, et al. Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocr J 2006; 53: 503-10.
Al-Timimi DJ, Ali AF. Serum 25(OH) D in diabetes mellitus type 2: relation to glycaemic control. J Clin Diagn Res 2013; 7: 2686-8.
Yilmaz H, Kaya M, Sahin M, Delibasi T. Is vitamin D status a predictor glycaemic regulation and cardiac complication in type 2 diabetes mellitus patients? Diabetes MetabSyndr 2012; 6: 28-31.
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